Iranian scientist pioneers 3D heart tissue model for disease research

A major advance in modern medicine has been achieved by an Iranian researcher, who has led the development of a three-dimensional model of human heart tissue that can contract autonomously, as reported by Nour News, a partner of TV BRICS.

Using advanced tissue engineering techniques, the research team under the leadership of Iranian scientist Homayoun Sadeghi successfully created a functional 3D cardiac structure in laboratory conditions, designed to closely replicate the mechanical and biological behaviour of human heart tissue.

Unlike many existing experimental platforms, the newly developed model allows researchers to collect highly precise, real-time mechanical data. This capability makes it possible to observe how heart tissue responds to stress, damage, and therapeutic interventions with far greater accuracy than traditional two-dimensional cell cultures.

The research team is now applying the technology to model a range of cardiovascular conditions, including dilated cardiomyopathy and certain forms of cardiac arrhythmia. By comparing heart tissue grown from patients with known cardiac diseases to samples derived from healthy cells, scientists aim to gain deeper insights into disease mechanisms at the cellular level.

According to the researchers, the platform has the potential to transform preclinical testing by enabling more reliable evaluation of new treatment approaches before they reach clinical trials. In the longer term, the technology could support the development of personalised therapies.

Experts note that such advances are crucial as cardiovascular diseases remain one of the leading causes of mortality worldwide. The ability to recreate human heart tissue in a controlled laboratory environment is expected to accelerate research, improve diagnostic precision, and enhance the safety and effectiveness of future therapies.