Indian scientists develop breakthrough nanoformulation for safer Parkinson’s treatment
This innovative nanoformulation prevents mitochondrial damage by inhibiting the translocation of calpain
Indian researchers have unveiled a groundbreaking nanoformulation designed to enhance the safety and effectiveness of Parkinson’s disease treatment. This is reported by IANS, a partner of TV BRICS.
The group of scientists has developed a targeted drug delivery system that enables the sustained release of 17β-oestradiol (E2), a hormone essential for managing Parkinson’s symptoms.
Parkinson’s disease, a progressive neurodegenerative disorder, is linked to an imbalance of 17β-oestradiol in the brain. However, the widespread use of this hormone in therapy has been limited due to its potential side effects and an incomplete understanding of its molecular mechanisms. To address these challenges, researchers have utilised dopamine receptor D3 (DRD3)-conjugated chitosan nanoparticles to precisely deliver 17β-oestradiol to the brain, significantly improving its therapeutic potential.
This innovative nanoformulation prevents mitochondrial damage by inhibiting the translocation of calpain.
The study further revealed a breakthrough in understanding the role of BMI1, a key regulator of mitochondrial homeostasis, in Parkinson’s disease, the source claims. The nanoformulation successfully restored BMI1 expression by preventing its degradation through calpain inhibition, highlighting a new potential target for neuroprotective therapies.
Photo: iStock
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Society13.09.26BRICS News Digest for the previous week
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![Ashok Mondal]()
Ashok MondalNID Director"Signing this Memorandum of Understanding between the National Institute of Design (NID) and TV BRICS marks a pivotal milestone in advancing design diplomacy across the BRICS media space. This moment is especially significant as India hosts the 18th BRICS Summit, following India’s assumption of the BRICS chairship under the visionary leadership of Prime Minister Shri Narendra Modi. The partnership directly embodies his call to elevate Indian design standards through 'Design in India, Design for the World'. Through the global reach and broadcast capabilities of TV BRICS, we are excited to showcase the extraordinary visual storytelling, films, and design research of NID’s Film and Video Communication students to an international audience, while also welcoming and screening film works from BRICS network countries at NID Ahmedabad. This reciprocal exchange strengthens our shared commitment to educational, cultural, and artistic collaboration, fostering sustainable connections among global creative communities. NID Ahmedabad looks forward to leveraging this partnership to deepen cross-cultural dialogue, build international expert networks, and unlock transformative opportunities for filmmakers, researchers, and faculty across member nations" -
![Vladimir Putin]()
Vladimir PutinPresident of Russia"We are developing mutual trade, which is growing; it increased by over 12 per cent last year. We have a joint commission working in this sphere. Our focus is on agriculture, shipbuilding, information technology and energy, including nuclear power. We have signed a free trade agreement between the Eurasian Economic Union and Indonesia. Jakarta is our reliable and old friend within ASEAN. We are working together at all international platforms, including the UN" -
![Joao Paulo Capobianco]()
Joao Paulo CapobiancoBrazilian Minister of the Environment and Climate Change"The BRICS countries have a very high level of responsibility because they share an important part of the world's biodiversity, landscapes, populations, food production and water resources. So, we have an opportunity to lead by example. We have our development bank, which can demonstrate and develop new ways of financing programmes. We can reduce the risks for private capital to invest in restoration and efforts to combat desertification" -
![Dilma Rousseff]()
Dilma RousseffPresident of the New Development Bank"India’s BRICS Presidency this year gives special significance to our discussion. NDB stands ready to be a trusted partner in turning commitments on sustainability, clean energy, smart and resilient infrastructure into concrete results on the ground. […] For NDB, mobilising private capital is a strategic imperative. Created by the BRICS founding members, NDB is a bank of the Global South, for the Global South, mandated to mobilise resources for infrastructure and sustainable development" -
![Sihasak Phuangketkeow]()
Sihasak PhuangketkeowDeputy Prime Minister and Minister of Foreign Affairs of Thailand"BRICS can play a very important role in maintaining the free flow of trade and investment. The group can also be a vehicle for all of us to engage and to look at economic opportunities"
