Indian scientists identify common biomarkers for early detection of pancreatic and glioma cancers

Indian researchers have identified common metabolites associated with pancreatic and glioma cancers, paving the way for improved early diagnosis and more effective treatments. This is reported by IANS, a partner of TV BRICS.

The study focused on metabolites found in exosomes – nano-sized vesicles that carry tumour-derived compounds – originating from pancreatic, lung, and glioma cancer cell lines. These biomarkers offer a promising non-invasive method for early detection, addressing a critical gap in diagnosing aggressive cancers that are often identified in advanced stages.

The research team employed a multi-technique approach that integrated Nanoparticle Tracking Analysis (NTA), Electron Microscopy (EM), Western Blot (WB), Fourier Transformed Infrared Spectroscopy (FTIR), untargeted Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR). This comprehensive methodology provides a more precise characterisation of exosomes compared to conventional single-method studies, as reported by the source.

Experts believe this breakthrough could significantly improve treatment efficacy, particularly through personalised therapies designed to interfere with dysregulated metabolic pathways in cancer cells. Such targeted interventions hold the potential to reduce side effects and enhance patient outcomes, marking a significant step forward in cancer diagnostics and therapeutics, the source claims.

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